Oestradiol implants and human safety
The use of oestradiol implants in beef production poses no risk to human safety when used in accordance with the label directions. All meat and many plants contain hormones. There is no such thing as ‘hormone-free’ meat or plant-based foods.
Humans are exposed to hormones throughout their life from synthesis in their own bodies, various medications and many common foodstuffs, e.g.:
- A non-pregnant woman produces daily about 54,000 times the amount of oestrogen found in a 500 gram steak from an implanted steer.2
- An adult man produces daily about 13,500 times the amount of oestrogen found in a 500 gram steak from an implanted steer.2
The U.S. Food & Drug Administration has determined that an incremental increase of hormones in beef muscle tissue of less than 1% of the lowest daily human production rate is deemed to be safe for human consumption.3 The levels of hormones supplied by Elanco's registered oestradiol implants are well within these limits. This high margin of safety is reflected by the nil meat withholding period for Elanco's registered oestradiol implants.
1. Figures assume a 15.8% liveweight gain advantage in cattle gaining 0.5 kg/day over 400 days, $3.17/kg liveweight and 100 implants per box.2. BF1522. 3. BF558.4. Therapeutics Goods Administration 2003. A review to update Australia’s position on the human safety of residues of HGPs used in cattle, Chemical Review and International Harmonisation Section Office of Chemical Safety Accessed 30th October 2014, http://apvma.gov.au/sites/default/files/hgp-review.pdf, pp. 1-175.5. BF5330. 6. BF5951. 7. BF6583.
^Image for display purposes only. Please read and follow the instructions on the approved Compudose 400 label.